A Retrospective Multicenter Italian Analysis of Epidemiological, Clinical and Histopathological Features in a Sample of Patients with Acinic Cell Carcinoma of the Parotid Gland.
Pietro De LucaArianna Di StadioLuca de CamporaEgidio De BonisMatteo FermiGerardo PetruzziFrancesca AtturoRoberta ColangeliAlfonso ScarpaAlfredo Lo MantoAndrea ColizzaGiulia CintoliGiulia TogoGiovanni SalzanoDomenico CrescenziMassimo RalliVincenzo AbbateFilippo RicciardielloLuciano MagaldiAurelio D'EcclesiaGianluca di MassaLeopoldo CostarelliElisabetta MerendaAlessandro CorsiRenato CovelloRosa Maria Di CrescenzoLoren DudaLucia Maria DimitriAlessandro CaputoGerardo FerraraTeresina LucanteFrancesco LongoDomenico TassoneMaurizio IemmaMichele CassanoFrancesco Antonio SalzanoLuigi CalifanoDaniele MarchioniRaul PelliniMarco de VincentiisLivio PresuttiFranco IonnaEnrico de CamporaMarco RadiciAngelo CamaioniPublished in: Cancers (2023)
AciCC generally had an indolent behavior, optimal OS, DFS with few cervical node metastases, and rare distant relapses. This multicenter retrospective case series provides evidence of the need for clinical-epidemiological-histological stratification for patients at risk of poor outcomes. Our results suggest that the correct definition of high-risk AciCC should include tumor size, the presence of necrosis, extraglandular spread, LVI, atypical mitosis, and cellular pleomorphism.