IL6-STAT3-C/EBPβ-IL6 positive feedback loop in tumor-associated macrophages promotes the EMT and metastasis of lung adenocarcinoma.

Zhengyang HuQihai SuiXing JinGuangyao ShanYiwei HuangYanjun YiDejun ZengMengnan ZhaoCheng ZhanQun WangZongwu LinTao LuZhencong Chen

Published in: Journal of experimental & clinical cancer research : CR (2024)

Our data suggest that TAMs promote IL-6 expression by forming an IL6-STAT3-C/EBPβ-IL6 positive feedback loop. Released IL-6 can induce the EMT pathway in lung cancer to enhance migration, invasion, and metastasis. The use of IL-6-neutralizing antibody can partially counteract the promotion of LUAD by TAMs. A novel mechanism of macrophage-promoted tumor progression was revealed, and the IL6-STAT3-C/EBPβ-IL6 signaling cascade may be a potential therapeutic target against lung cancer.

Keyphrases

poor prognosis
cell proliferation
signaling pathway
risk assessment
machine learning
climate change
zika virus
cell migration
deep learning
binding protein