Platelet-predominate gene expression and reticulated platelets in nonvalvular atrial fibrillation: Effect of pulmonary veins isolation.
Waldemar E WysokinskiAlfonso TafurYanhong WuNaser AmmashSamuel J AsirvathamIzabela Gosk-BierskaDiane E GrillJoshua P SlusserJozef MrukRobert D McBanePublished in: Journal of cardiovascular electrophysiology (2018)
NVAF is associated with notable downregulation of genes directing platelet production and size but increased RP content. PVI impacts the expression of many of these genes, implying a direct relationship between atrial fibrillation and platelet biogenesis.
Keyphrases
- atrial fibrillation
- gene expression
- oral anticoagulants
- left atrial appendage
- direct oral anticoagulants
- catheter ablation
- left atrial
- genome wide
- poor prognosis
- heart failure
- dna methylation
- pulmonary hypertension
- bioinformatics analysis
- cell proliferation
- percutaneous coronary intervention
- signaling pathway
- venous thromboembolism
- genome wide analysis
- left ventricular
- mitral valve
- coronary artery disease