LEF1 Induces DHRS2 Gene Expression in Human Acute Leukemia Jurkat T-Cells

Sema Sırma Ekmekçi Zeliha Emrence Neslihan Abacı Melda Sarıman Burcu Salman Cumhur Gökhan EkmekciÇağrı Güleç

Published in: Turkish journal of haematology : official journal of Turkish Society of Haematology (2020)

Our results revealed that DHRS2 is positively regulated by LEF1 in Jurkat cells, which indicates the capability of LEF1 as a tumor suppressor and, together with previous reports, suggests that LEF1 exhibits a regulatory role in T-ALL via not only its oncogenic targets but also tumor suppressor genes.

Keyphrases

gene expression
induced apoptosis
endothelial cells
transcription factor
dna methylation
cell cycle arrest
single cell
emergency department
induced pluripotent stem cells
cell proliferation
pluripotent stem cells