Differential expression of CD8 defines phenotypically distinct cytotoxic T cells in cancer and multiple sclerosis.
Tobias BurkardMartina Herrero San JuanCaroline DreisAnastasiia KiprinaDmitry NamgaladzeKai SiebenbrodtSebastian LugerChristian FoerchJosef M PfeilschifterAndreas WeigertHeinfried H RadekePublished in: Clinical and translational medicine (2022)
In summary, our data show that functionally distinct cytotoxic T lymphocytes can be identified based on their expression of CD8. Indicating a more general role in CD8 T cell immunity, these cells may play opposing roles in the TME, and also in the pathophysiology of autoimmune diseases such as multiple sclerosis.
Keyphrases
- multiple sclerosis
- induced apoptosis
- poor prognosis
- white matter
- papillary thyroid
- cell cycle arrest
- nk cells
- electronic health record
- squamous cell
- big data
- endoplasmic reticulum stress
- squamous cell carcinoma
- oxidative stress
- signaling pathway
- childhood cancer
- cell proliferation
- artificial intelligence
- long non coding rna
- anti inflammatory