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Human leucocyte antigens profiling in Malay female patients with systemic lupus erythematosus: are we the same or different?

Malarvili SelvarajaChun Lai TooLay Kim TanBee Tee KoayMaha AbdullahAnim Md ShahMasita AripSyafinaz Amin-Nordin
Published in: Lupus science & medicine (2022)
This study reveals multiple HLA alleles associated with susceptibility and protection against risk of developing SLE in Malay female population with renal disorders. In addition, the published data from different ethnic populations together with our study further support the notion that the genetic effects from association with DRB1*15:01/02, DQB1*03:01 and DQA1*01:02 alleles are generalised to multiple ethnic populations of Caucasian, African and Asian descents.
Keyphrases
  • systemic lupus erythematosus
  • randomized controlled trial
  • systematic review
  • gene expression
  • genome wide
  • rheumatoid arthritis
  • immune response
  • electronic health record
  • dna methylation
  • meta analyses