Network Pharmacology Approach to Explore the Potential Mechanisms of Jieduan-Niwan Formula Treating Acute-on-Chronic Liver Failure.

Jiajun LiangMengli WuChen BaiChongyang MaPeng FangWeixin HouXiaoyi WeiQiuyun ZhangYuqiong Du

Published in: Evidence-based complementary and alternative medicine : eCAM (2020)

The study predicted potential mechanisms of JDNW Formula in the treatment of ACLF, involving downregulation of inflammatory factor expression, antioxidant stress, and inhibition of hepatocyte apoptosis. JDNW Formula may improve mitochondrial quality in ACLF via the AMPK signaling pathway, which serves as a guide for further study.

Keyphrases

liver failure
oxidative stress
signaling pathway
hepatitis b virus
poor prognosis
human milk
skeletal muscle
endoplasmic reticulum stress
pi k akt
climate change
human health
anti inflammatory
induced apoptosis
quality improvement
protein kinase
respiratory failure