Curcumin induces G2/M arrest, apoptosis, NF-κB inhibition, and expression of differentiation genes in thyroid carcinoma cells.
Suzan SchwertheimFrederik WeinKlaus LennartzKarl WormKurt Werner SchmidSien-Yi Sheu-GrabellusPublished in: Journal of cancer research and clinical oncology (2017)
Curcumin increases the expression of redifferentiation markers and induces G2/M arrest, apoptosis, and downregulation of NF-κB activity in thyroid carcinoma cells. Thus, curcumin appears to be a promising agent to overcome resistance to the conventional cancer therapy.
Keyphrases
- cell cycle arrest
- pi k akt
- signaling pathway
- oxidative stress
- induced apoptosis
- poor prognosis
- endoplasmic reticulum stress
- cancer therapy
- cell death
- cell proliferation
- cell cycle
- lps induced
- drug delivery
- binding protein
- long non coding rna
- inflammatory response
- dna methylation
- transcription factor
- bioinformatics analysis
- genome wide identification