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The Folic Acid and Creatine Trial: Treatment Effects of Supplementation on Arsenic Methylation Indices and Metabolite Concentrations in Blood in a Bangladeshi Population.

Ahlam K AbuawadAnne K BozackAna Navas-AcienJeff GoldsmithXinhua LiuMegan N HallVesna IlievskiAngela M Lomax-LuuFaruque ParvezHasan ShahriarMohammad N UddinTariqul IslamJoseph H GrazianoMary V Gamble
Published in: Environmental health perspectives (2023)
FA supplementation lowered bMMAs and increased bDMAs in a sample of primarily folate-replete adults, whereas creatine supplementation lowered bMMAs. Evidence of the reversal of treatment effects on As metabolites following FA cessation suggests short-term benefits of supplementation and underscores the importance of long-term interventions, such as FA fortification. https://doi.org/10.1289/EHP11270.
Keyphrases
  • physical activity
  • clinical trial
  • randomized controlled trial
  • heavy metals
  • drinking water
  • phase iii
  • genome wide