Copper-Catalyzed Diamination of Oxime Ester-Tethered Unactivated Alkenes with Unprotected Amines.

In this protocol, a redox-neutral Cu-catalyzed two-component vicinal diamination of oxime ester-tethered unactivated alkenes has been developed. This operationally simple method employs unprotected amines as the source of nucleophilic nitrogen and requires no additional ligand, enabling the efficient synthesis of diverse pyrrolines under mild and oxidant-free conditions. On the basis of the control experiments, a radical reaction pathway was proposed for this Cu-catalyzed reaction.