CCR3 gene overexpression in patients with Down syndrome.
Michele SalemiRossella CannarellaGiovanna MarcheseMaria Grazia SalluzzoMaria RavoConcetta BaroneAngela CordellaSalvatore CanigliaRoberto CastiglioneAlda RagalmutoAldo E CalogeroCorrado RomanoPublished in: Molecular biology reports (2021)
Chromosome 21 trisomy or Down syndrome (DS) is the most common genetic cause of intellectual disability (ID). DS is also associated with hypotonia, muscle weakness, autoimmune diseases, and congenital heart disease. C-C chemokine receptor type 3 (CCR3) plays a role in inflammatory, autoimmune, and neuronal migration mechanisms. The present study aimed to evaluate the expression of the CCR3 gene by NGS and qRT-PCR in patients with DS and normal controls (NC). The CCR3 gene was over-expressed in DS patients compared to NC. These data suggest that an over-expression of the CCR3 gene is associated with the phenotype of patients with DS.
Keyphrases
- copy number
- genome wide
- intellectual disability
- dendritic cells
- congenital heart disease
- regulatory t cells
- poor prognosis
- genome wide identification
- end stage renal disease
- autism spectrum disorder
- chronic kidney disease
- binding protein
- oxidative stress
- multiple sclerosis
- transcription factor
- cell proliferation
- newly diagnosed
- skeletal muscle
- machine learning
- long non coding rna
- electronic health record
- patient reported outcomes
- big data
- cerebral ischemia