Cerebrospinal fluid neurofilament light predicts longitudinal diagnostic change in patients with psychiatric and neurodegenerative disorders.
Matthew J Y KangDhamidhu EratneHannah DobsonCharles B MalpasMichael KeemCourtney LewisJasleen GrewalVivian TsoukraChrista DangRamon MocellinTomas KalincikAlexander F SantilloHenrik ZetterbergKaj BlennowChristiane StehmannShiji VargheseQiao-Xin LiColin L MastersSteven John CollinsSamuel Frank BerkovicAndrew Howard EvansWendy KelsoSarah FarrandSamantha M Loi Franzcp PhD MbbsMark WalterfangDennis VelakoulisPublished in: Acta neuropsychiatrica (2023)
CSF NfL improved diagnostic accuracy, with potential to have led to earlier, accurate diagnosis in a real-world setting using a pre-specified cut-off, adding weight to translation of NfL into clinical practice.