Tumor Suppressive Effects of GAS5 in Cancer Cells.
Jesminder KaurNur'ain SalehenAnwar NorazitAmirah Abdul RahmanNor Azian Abdul MuradNik Mohd Afizan Nik Abd RahmanKamariah IbrahimPublished in: Non-coding RNA (2022)
In recent years, long non-coding RNAs (lncRNAs) have been shown to play important regulatory roles in cellular processes. Growth arrests specific transcript 5 (GAS5) is a lncRNA that is highly expressed during the cell cycle arrest phase but is downregulated in actively growing cells. Growth arrests specific transcript 5 was discovered to be downregulated in several cancers, primarily solid tumors, and it is known as a tumor suppressor gene that regulates cell proliferation, invasion, migration, and apoptosis via multiple molecular mechanisms. Furthermore, GAS5 polymorphism was found to affect GAS5 expression and functionality in a cell-specific manner. This review article focuses on GAS5's tumor-suppressive effects in regulating oncogenic signaling pathways, cell cycle, apoptosis, tumor-associated genes, and treatment-resistant cells. We also discussed genetic polymorphisms of GAS5 and their association with cancer susceptibility.
Keyphrases
- cell cycle arrest
- pi k akt
- cell death
- cell proliferation
- cell cycle
- room temperature
- long non coding rna
- signaling pathway
- induced apoptosis
- poor prognosis
- endoplasmic reticulum stress
- carbon dioxide
- oxidative stress
- stem cells
- squamous cell carcinoma
- single cell
- cell therapy
- epithelial mesenchymal transition
- gene expression
- copy number
- ionic liquid
- genome wide analysis