Analysis of common genetic variation and rare CNVs in the Australian Autism Biobank.
Chloe X YapGail A AlvaresAnjali K HendersTian LinLeanne WallaceAlaina FarrellyTiana McLarenJolene BerryAnna A E VinkhuyzenMaciej TrzaskowskiJian ZengYuanhao YangDominique B ClearyRachel GroveClaire HafekostAlexis HarunHelen HoldsworthRachel JellettFeroza KhanLauren P LawsonJodie LeslieMira Levis FrenkAnne MasiNisha E MathewMelanie MuniandyMichaela NothardPeter M VisscherPaul A DawsonCheryl DissanayakeValsamma EapenHelen S HeusslerAndrew J O WhitehouseNaomi R WrayJacob GrattenPublished in: Molecular autism (2021)
We report on common genetic variation and rare CNVs within the AAB. Prediction analyses using currently available GWAS summary statistics are largely consistent with expected relationships based on published studies. As the size of publicly-available GWAS summary statistics grows, the phenotypic depth of the AAB dataset will provide many opportunities for analyses of autism profiles and co-occurring conditions, including when integrated with other omics datasets generated from AAB biospecimens (blood, urine, stool, hair).