Balanced forced-diuresis compared to control as a reno-protective approach in cardiac surgery: secondary outcome of a randomized controlled trial, assessment of neutrophil gelatinase-associated lipocalin levels.
Heyman LuckrazRamesh GiriBenjamin WrigleyKumaresan NagarajanEshan SenanayakeEmma SharmanLawrence BeareAlan NevillPublished in: Journal of cardiothoracic surgery (2021)
Overall, the 6-h post-CPB plasma NGAL levels were significantly higher in patients who developed AKI. Patients managed with the novel approach of balanced forced-diuresis, provided by the RenalGuard® system, had a lower AKI rate and lower NGAL levels indicating a lesser degree of renal tissue injury. Trial registration ClinicalTrials.gov website, NCT02974946, https://clinicaltrials.gov/ct2/show/NCT02974946 .
Keyphrases
- acute kidney injury
- cardiac surgery
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- ejection fraction
- prognostic factors
- computed tomography
- clinical trial
- study protocol
- peritoneal dialysis
- randomized controlled trial
- magnetic resonance imaging
- contrast enhanced
- phase iii
- patient reported outcomes
- positron emission tomography
- dual energy
- clinical evaluation