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Comprehensive analysis of the efficacy and safety of CAR T-cell therapy in patients with relapsed or refractory B-cell acute lymphoblastic leukaemia: a systematic review and meta-analysis.

Sebastian Emmanuel WillyantoYohanes Audric AlimsjahKrisanto TanjayaAekkachai TuekprakhonAulia Rahmi Pawestri
Published in: Annals of medicine (2024)
Choosing a more efficacious and safer CAR T-cell treatment is crucial for improving overall survival in acute leukaemia. Beyond the promising anti-CD22 CAR T-cell, exploring costimulatory domains and new CD targets could enhance treatment effectiveness for r/r B-ALL.
Keyphrases
  • cell therapy
  • liver failure
  • randomized controlled trial
  • systematic review
  • stem cells
  • acute lymphoblastic leukemia
  • diffuse large b cell lymphoma
  • combination therapy
  • intensive care unit
  • nk cells
  • bone marrow