Is the Transcription Factor NANOG Involved in Placental Aging?
Sivan Farladansky-GershnabelMichal SilberTal Biron-ShentalMichal KovoDebora KidronAvivit WeiszTali Zitman-GalPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2024)
The elevated expression of NANOG and KLF4 in abnormal placental tissues suggests their potential role as markers of enhanced placental aging and dysfunction. These findings underscore the importance of the KLF4-NANOG pathway in the pathology of PE, FGR, and PTB, providing a basis for future research into therapeutic targets for these conditions.