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Optimized Management of Nivolumab and Ipilimumab in Advanced Renal Cell Carcinoma: A Response-Based Phase II Study (OMNIVORE).

Rana R McKayBradley Alexander McGregorWanling XieDavid A BraunXiao WeiChristos E KyriakopoulosYousef ZakhariaBenjamin L MaughanTracy L RoseWalter M StadlerDavid F McDermottLauren C HarshmanToni K Choueiri
Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2020)
In this study, nivolumab followed by two doses of ipilimumab resulted in no CRs and a low PR/CR conversion. The number of patients evaluated for nivolumab discontinuation was too small to assess the value of this approach. Currently, our data do not support a response-adaptive strategy for checkpoint blockade in advanced RCC.
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