Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease.
Kasper W Ter HorstDaniel F VatnerDaniel F VatnerGary W ClineMariette T AckermansAart J NederveenJoanne VerheijAhmet DemirkiranBart A van WagensveldGeesje M Dallinga-ThieMax NieuwdorpJohannes A RomijnGerald I ShulmanMireille J SerliePublished in: Diabetes care (2020)
Acute increases in lipogenesis in humans with NAFLD are not explained by altered molecular regulation of lipogenesis through a paradoxical increase in lipogenic insulin action; rather, increases in lipogenic substrate availability may be the key.