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Gerald I Shulman

ORCID

Publication Activity (10 Years)

Years Active: 2016-2023
Publications (10 Years): 40

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Nature communications

Diabetes

American journal of physiology. Endocrinology and metabolism

Yale University School of Medicine

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Yale University School of Medicine Jul 1o 1987

United States

George R. Cowgill Professor of Medicine and Cellular & Molecular Physiology :: Internal Medicine and Cellular & Molecular Physiology

Publications

Panu K Luukkonen, Ikki Sakuma, Rafael C Gaspar, Meghan Mooring, Ali Nasiri, Mario Kahn, Xian-Man Zhang, Dongyan Zhang, Henna Sammalkorpi, Anne K Penttilä, Marju Orho-Melander, Johanna Arola, Anne Juuti, Xuchen Zhang, Dean Yimlamai, Hannele Yki-Järvinen, Kitt Falk Petersen, Gerald I Shulman
Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis. Proceedings of the National Academy of Sciences of the United States of America 120 (4) (2023)
Panu K Luukkonen, Ikki Sakuma, Rafael C Gaspar, Meghan Mooring, Ali Nasiri, Mario Kahn, Xian-Man Zhang, Dongyan Zhang, Henna Sammalkorpi, Anne K Penttilä, Marju Orho-Melander, Johanna Arola, Anne Juuti, Xuchen Zhang, Dean Yimlamai, Hannele Yki-Järvinen, Kitt Falk Petersen, Gerald I Shulman
Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis. Proceedings of the National Academy of Sciences of the United States of America 120 (4) (2023)
Meghan S Mooring, Grace A Yeung, Panu K Luukkonen, Silvia Liu, Muhammad Waqas Akbar, Gary J Zhang, Oluwashanu Balogun, Xuemei Yu, Rigen Mo, Kari Nejak-Bowen, Masha V Poyurovsky, Carmen J Booth, Liza Konnikova, Gerald I Shulman, Dean Yimlamai
Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis. Science translational medicine 15 (715) (2023)
Panu K Luukkonen, Ikki Sakuma, Rafael C Gaspar, Meghan Mooring, Ali Nasiri, Mario Kahn, Xian-Man Zhang, Dongyan Zhang, Henna Sammalkorpi, Anne K Penttilä, Marju Orho-Melander, Johanna Arola, Anne Juuti, Xuchen Zhang, Dean Yimlamai, Hannele Yki-Järvinen, Kitt Falk Petersen, Gerald I Shulman
Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis. Proceedings of the National Academy of Sciences of the United States of America 120 (4) (2023)
Panu K Luukkonen, Ikki Sakuma, Rafael C Gaspar, Meghan Mooring, Ali Nasiri, Mario Kahn, Xian-Man Zhang, Dongyan Zhang, Henna Sammalkorpi, Anne K Penttilä, Marju Orho-Melander, Johanna Arola, Anne Juuti, Xuchen Zhang, Dean Yimlamai, Hannele Yki-Järvinen, Kitt Falk Petersen, Gerald I Shulman
Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis. Proceedings of the National Academy of Sciences of the United States of America 120 (4) (2023)
Panu K Luukkonen, Ikki Sakuma, Rafael C Gaspar, Meghan Mooring, Ali Nasiri, Mario Kahn, Xian-Man Zhang, Dongyan Zhang, Henna Sammalkorpi, Anne K Penttilä, Marju Orho-Melander, Johanna Arola, Anne Juuti, Xuchen Zhang, Dean Yimlamai, Hannele Yki-Järvinen, Kitt Falk Petersen, Gerald I Shulman
Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis. Proceedings of the National Academy of Sciences of the United States of America 120 (4) (2023)
Panu K Luukkonen, Ikki Sakuma, Rafael C Gaspar, Meghan Mooring, Ali Nasiri, Mario Kahn, Xian-Man Zhang, Dongyan Zhang, Henna Sammalkorpi, Anne K Penttilä, Marju Orho-Melander, Johanna Arola, Anne Juuti, Xuchen Zhang, Dean Yimlamai, Hannele Yki-Järvinen, Kitt Falk Petersen, Gerald I Shulman
Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis. Proceedings of the National Academy of Sciences of the United States of America 120 (4) (2023)
Panu K Luukkonen, Ikki Sakuma, Rafael C Gaspar, Meghan Mooring, Ali Nasiri, Mario Kahn, Xian-Man Zhang, Dongyan Zhang, Henna Sammalkorpi, Anne K Penttilä, Marju Orho-Melander, Johanna Arola, Anne Juuti, Xuchen Zhang, Dean Yimlamai, Hannele Yki-Järvinen, Kitt Falk Petersen, Gerald I Shulman
Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis. Proceedings of the National Academy of Sciences of the United States of America 120 (4) (2023)
Panu K Luukkonen, Ikki Sakuma, Rafael C Gaspar, Meghan Mooring, Ali Nasiri, Mario Kahn, Xian-Man Zhang, Dongyan Zhang, Henna Sammalkorpi, Anne K Penttilä, Marju Orho-Melander, Johanna Arola, Anne Juuti, Xuchen Zhang, Dean Yimlamai, Hannele Yki-Järvinen, Kitt Falk Petersen, Gerald I Shulman
Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis. Proceedings of the National Academy of Sciences of the United States of America 120 (4) (2023)
Panu K Luukkonen, Ikki Sakuma, Rafael C Gaspar, Meghan Mooring, Ali Nasiri, Mario Kahn, Xian-Man Zhang, Dongyan Zhang, Henna Sammalkorpi, Anne K Penttilä, Marju Orho-Melander, Johanna Arola, Anne Juuti, Xuchen Zhang, Dean Yimlamai, Hannele Yki-Järvinen, Kitt Falk Petersen, Gerald I Shulman
Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis. Proceedings of the National Academy of Sciences of the United States of America 120 (4) (2023)
Hui-Young Lee, Hye Rim Jang, Hui Li, Varman T Samuel, Karrie D Dudek, Anna B Osipovich, Mark A Magnuson, Jeffrey Sklar, Gerald I Shulman
Deletion of Jazf1 gene causes early growth retardation and insulin resistance in mice. Proceedings of the National Academy of Sciences of the United States of America 119 (49) (2022)
Traci E LaMoia, Gina M Butrico, Hasini A Kalpage, Leigh Goedeke, Brandon T Hubbard, Daniel F Vatner, Rafael C Gaspar, Xian-Man Zhang, Gary W Cline, Keita Nakahara, Seungwan Woo, Atsuhiro Shimada, Maik Hüttemann, Gerald I Shulman
Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis. Proceedings of the National Academy of Sciences of the United States of America 119 (10) (2022)
Leigh Goedeke, Kelsey N Murt, Andrea Di Francesco, João Paulo Camporez, Ali R Nasiri, Yongliang Wang, Xian-Man Zhang, Gary W Cline, Rafael de Cabo, Gerald I Shulman
Sex- and strain-specific effects of mitochondrial uncoupling on age-related metabolic diseases in high-fat diet-fed mice. Aging cell 21 (2) (2022)
Leigh Goedeke, Alberto Canfrán-Duque, Noemi Rotllan, Balkrishna Chaube, Bonne M Thompson, Richard G Lee, Gary W Cline, Jeffrey G McDonald, Gerald I Shulman, Miguel A Lasunción, Yajaira Suárez, Carlos Fernández-Hernando
MMAB promotes negative feedback control of cholesterol homeostasis. Nature communications 12 (1) (2021)
Kitt Falk Petersen, Douglas L Rothman, Gerald I Shulman
Reply to Carter et al.: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes. American journal of physiology. Endocrinology and metabolism 320 (5) (2021)
Qian Wang, Dehai Li, Guangchao Cao, Qiping Shi, Jing Zhu, Mingyue Zhang, Hao Cheng, Qiong Wen, Hao Xu, Leqing Zhu, Hua Zhang, Rachel J Perry, Olga Spadaro, Yunfan Yang, Shengqi He, Yong Chen, Baocheng Wang, Guangqiang Li, Zonghua Liu, Caixian Yang, Xiaoli Wu, Libing Zhou, Qinghua Zhou, Zhenyu Ju, Hongyun Lu, Yongjie Xin, Xiaoyong Yang, Cunchuan Wang, Yong Liu, Gerald I Shulman, Vishwa Deep Dixit, Ligong Lu, Hengwen Yang, Richard A Flavell, Zhinan Yin
IL-27 signalling promotes adipocyte thermogenesis and energy expenditure. Nature 600 (7888) (2021)
Kitt Falk Petersen, Douglas L Rothman, Gerald I Shulman
Point: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes. American journal of physiology. Endocrinology and metabolism 320 (5) (2021)
Rafael C Gaspar, José R Pauli, Gerald I Shulman, Vitor Rosetto Muñoz
An update on brown adipose tissue biology: a discussion of recent findings. American journal of physiology. Endocrinology and metabolism 320 (3) (2021)
Tina Schumann, Jörg König, Christian von Loeffelholz, Daniel F Vatner, Dongyan Zhang, Rachel J Perry, Michel Bernier, Jason Chami, Christine Henke, Anica Kurzbach, Nermeen N El-Agroudy, Diana M Willmes, Dominik Pesta, Rafael de Cabo, John F O Sullivan, Eric Simon, Gerald I Shulman, Bradford S Hamilton, Andreas L Birkenfeld
Publisher Correction: Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Communications biology 4 (1) (2021)
Estifanos N Habtemichael, Don T Li, Joao Paulo Camporez, Xavier O Westergaard, Chloe I Sales, Xinran Liu, Francesc Lopez, Stephen G DeVries, Hanbing Li, Diana M Ruiz, Kenny Y Wang, Bhavesh S Sayal, Sofia González Zapata, Pamela Dann, Stacey N Brown, Sandro Hirabara, Daniel F Vatner, Leigh Goedeke, William Philbrick, Gerald I Shulman, Jonathan S Bogan
Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake. Nature metabolism 3 (3) (2021)
Tina Schumann, Jörg König, Christian von Loeffelholz, Daniel F Vatner, Dongyan Zhang, Rachel J Perry, Michel Bernier, Jason Chami, Christine Henke, Anica Kurzbach, Nermeen N El-Agroudy, Diana M Willmes, Dominik Pesta, Rafael de Cabo, John F O Sullivan, Eric Simon, Gerald I Shulman, Bradford S Hamilton, Andreas L Birkenfeld
Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Communications biology 4 (1) (2021)
Xiruo Li, Dongyan Zhang, Daniel F Vatner, Leigh Goedeke, Sandro Massao Hirabara, Ye Zhang, Rachel J Perry, Gerald I Shulman
Mechanisms by which adiponectin reverses high fat diet-induced insulin resistance in mice. Proceedings of the National Academy of Sciences of the United States of America 117 (51) (2020)
Myoung Sook Han, Rachel J Perry, Joao Paulo Camporez, Jan-Bernd Funcke, Gerald I Shulman, Guangping Gao, Roger J Davis
A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21. Genes & development 35 (1-2) (2020)
Kasper W Ter Horst, Daniel F Vatner, Daniel F Vatner, Gary W Cline, Mariette T Ackermans, Aart J Nederveen, Joanne Verheij, Ahmet Demirkiran, Bart A van Wagensveld, Geesje M Dallinga-Thie, Max Nieuwdorp, Johannes A Romijn, Gerald I Shulman, Mireille J Serlie
Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease. Diabetes care 44 (2) (2020)
Rachel J Perry, Gerald I Shulman
Sodium-glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks. The Journal of biological chemistry 295 (42) (2020)
Yunfan Yang, Xiruo Li, Harding H Luan, Bichen Zhang, Kaisi Zhang, Jin Hyun Nam, Zongyu Li, Minnie Fu, Alexander Munk, Dongyan Zhang, Simeng Wang, Yuyang Liu, João Paulo Albuquerque, Qunxiang Ong, Rui Li, Qi Wang, Marie E Robert, Rachel J Perry, Dongjun Chung, Gerald I Shulman, Xiaoyong Yang
OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance. Proceedings of the National Academy of Sciences of the United States of America 117 (28) (2020)
Rachel J Perry, Dongyan Zhang, Mateus T Guerra, Allison L Brill, Leigh Goedeke, Ali R Nasiri, Aviva Rabin-Court, Yongliang Wang, Liang Peng, Sylvie Dufour, Ye Zhang, Xian-Man Zhang, Gina M Butrico, Keshia Toussaint, Yuichi Nozaki, Gary W Cline, Kitt Falk Petersen, Michael H Nathanson, Barbara E Ehrlich, Gerald I Shulman
Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis. Nature 579 (7798) (2020)
Leigh Goedeke, Liang Peng, Valle Montalvo-Romeral, Gina M Butrico, Sylvie Dufour, Xian-Man Zhang, Rachel J Perry, Mariette T Ackermans, Paul Kievit, Keefe Chng, Kitt Falk Petersen, Gerald I Shulman
Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates. Science translational medicine 11 (512) (2020)
Liyang Zhao, Florencia Pascual, Lawrence Bacudio, Amanda L Suchanek, Pamela A Young, Lei O Li, Sarah A Martin, Joao-Paulo Camporez, Rachel J Perry, Gerald I Shulman, Eric L Klett, Rosalind A Coleman
Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1 deficiency increases amino acid use and impairs muscle function. The Journal of biological chemistry 294 (22) (2019)
Jin-Ho Koh, Matthew L Johnson, Surendra Dasari, Nathan K LeBrasseur, Ivan Vuckovic, Gregory C Henderson, Shawna A Cooper, Shankarappa Manjunatha, Gregory N Ruegsegger, Gerald I Shulman, Ian R Lanza, K Sreekumaran Nair
TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet-Induced Insulin Resistance in Skeletal Muscle. Diabetes 68 (8) (2019)
Rachel J Perry, Aviva Rabin-Court, Joongyu D Song, Rebecca L Cardone, Yongliang Wang, Richard G Kibbey, Gerald I Shulman
Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats. Nature communications 10 (1) (2019)
Nicolás Gómez-Banoy, J Sawalla Guseh, Ge Li, Alfonso Rubio-Navarro, Tong Chen, BreAnne Poirier, Gregory Putzel, Carolina Rosselot, Maria A Pabón, João Paulo Camporez, Vijeta Bhambhani, Shih-Jen Hwang, Chen Yao, Rachel J Perry, Sushmita Mukherjee, Martin G Larson, Daniel Levy, Lukas E Dow, Gerald I Shulman, Noah Dephoure, Adolfo Garcia-Ocana, Mingming Hao, Bruce M Spiegelman, Jennifer E Ho, James C Lo
Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans. Nature medicine 25 (11) (2019)
Jessica Nouws, Mark Fitch, Mariana Mata, Nicola Santoro, Brittany Galuppo, Romy Kursawe, Deepak Narayan, Alla Vash-Margita, Bridget Pierpont, Gerald I Shulman, Marc Hellerstein, Sonia Caprio
Altered In Vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues Are Associated With the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls. Diabetes 68 (6) (2019)
Anila K Madiraju, Yang Qiu, Rachel J Perry, Yasmeen Rahimi, Xian-Man Zhang, Dongyan Zhang, João-Paulo G Camporez, Gary W Cline, Gina M Butrico, Bruce E Kemp, Gregori Casals, Gregory R Steinberg, Daniel F Vatner, Kitt F Petersen, Gerald I Shulman
Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo. Nature medicine 24 (9) (2018)
Feng Zhang, Georgia Zarkada, Jinah Han, Jinyu Li, Alexandre Dubrac, Roxana Ola, Gael Genet, Kevin Boyé, Pauline Michon, Steffen E Künzel, Joao Paulo Camporez, Abhishek K Singh, Guo-Hua Fong, Michael Simons, Patrick Tso, Carlos Fernández-Hernando, Gerald I Shulman, William C Sessa, Anne Eichmann
Lacteal junction zippering protects against diet-induced obesity. Science (New York, N.Y.) 361 (6402) (2018)
Rachel J Perry, Liang Peng, Gary W Cline, Gina M Butrico, Yongliang Wang, Xian-Man Zhang, Douglas L Rothman, Kitt Falk Petersen, Gerald I Shulman
Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA). Nature communications 9 (1) (2018)
Ahmed Lawan, Kisuk Min, Lei Zhang, Alberto Canfran-Duque, Michael J Jurczak, Joao Paulo G Camporez, Yaohui Nie, Timothy P Gavin, Gerald I Shulman, Carlos Fernandez-Hernando, Anton M Bennett
Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance. Diabetes 67 (4) (2018)
Kevin C Corbit, João Paulo G Camporez, Lia R Edmunds, Jennifer L Tran, Nicholas B Vera, Derek M Erion, Rahul C Deo, Rachel J Perry, Gerald I Shulman, Michael J Jurczak, Ethan J Weiss
Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. Diabetes 67 (2) (2017)
Rachel J Perry, Liang Peng, Gary W Cline, Gina M Butrico, Yongliang Wang, Xian-Man Zhang, Douglas L Rothman, Kitt Falk Petersen, Gerald I Shulman
Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA). Nature communications 8 (1) (2017)
Arvindhan Nagarajan, Max C Petersen, Ali R Nasiri, Gina Butrico, Annie Fung, Hai-Bin Ruan, Romy Kursawe, Sonia Caprio, Jacques Thibodeau, Marie-Claude Bourgeois-Daigneault, Lisha Sun, Guangping Gao, Sanjay Bhanot, Michael J Jurczak, Michael R Green, Gerald I Shulman, Narendra Wajapeyee
MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. Nature communications 7 (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Gerald I Shulman