Locoregional Therapies for Hepatobiliary Tumors: Contemporary Strategies and Novel Applications.
Andrei M JipaMina S MakaryPublished in: Cancers (2024)
A large majority of primary hepatobiliary tumors are hepatocellular carcinomas (HCC), with the remainer being cholangiocarcinoma. While surgical resection remains the gold standard treatment for hepatobiliary tumors, relatively few patients are operative candidates, and systemic treatments have limited effectiveness. Locoregional therapies offer significant promise in the management of HCC. Ablation and radioembolization may offer similar outcomes to surgery for early-stage hepatocellular carcinoma while radioembolization and chemoembolization are valuable in the management of advanced disease. There is significantly less evidence for the role of locoregional therapy in the treatment of cholangiocarcinoma, although it appears to be well tolerated.
Keyphrases
- early stage
- end stage renal disease
- randomized controlled trial
- ejection fraction
- minimally invasive
- systematic review
- high grade
- squamous cell carcinoma
- prognostic factors
- coronary artery bypass
- radiation therapy
- big data
- machine learning
- mesenchymal stem cells
- peritoneal dialysis
- patient reported outcomes
- locally advanced
- percutaneous coronary intervention
- bone marrow
- cell therapy