Antibacterial activity of bacteria isolated from Phragmites australis against multidrug-resistant human pathogens.
Vania DelfinoCarmela CalonicoAntonella Lo NostroLara Mitia CastronovoSara Del DucaSofia ChioccioliEster CoppiniDonatella FibbiAlberto VassalloRenato FaniPublished in: Future microbiology (2021)
Background: Rising number of multidrug-resistant human pathogens demands novel antibiotics: to this aim, unexplored natural sources are investigated to find new compounds. In this context, bacteria associated to medicinal plants, including Phragmites australis, might represent an important source of antimicrobial compounds. Materials & methods: In the present work, 21 bacterial endophytes isolated from P. australis roots were tested, by cross-streaking, for their inhibitory activity against 36 multidrug-resistant pathogens isolated from food, clinical patients and hospitals. Results & conclusion: Seven endophytes, belonging to Pseudomonas and Stenotrophomonas, were able to inhibit the growth of most of the target strains. In conclusion, this preliminary work could pave the way for the discovery of new antibiotics against superbugs.
Keyphrases
- multidrug resistant
- gram negative
- drug resistant
- acinetobacter baumannii
- endothelial cells
- klebsiella pneumoniae
- end stage renal disease
- induced pluripotent stem cells
- newly diagnosed
- escherichia coli
- ejection fraction
- healthcare
- antimicrobial resistance
- pluripotent stem cells
- staphylococcus aureus
- peritoneal dialysis
- small molecule
- prognostic factors
- high throughput
- mass spectrometry
- atomic force microscopy