Angiotensin converting enzyme 2 and angiotensin (1-7) axis in pulmonary arterial hypertension.

Julio SandovalLeonardo Del Valle-MondragonFelipe MassoNayeli ZayasTomás PulidoRicardo TeijeiroHector Gonzalez-PachecoRossana Olmedo-OcampoCarlos SisniegaAraceli Paez-ArenasGustavo Pastelin-HernandezJose Gomez-ArroyoNorbert F Voelkel

Published in: The European respiratory journal (2020)

The AngII-ACE2-Ang(1-7) axis appears to be altered in human PAH and we propose that this imbalance, in favour of AngII, plays a role in the pathogenesis of the severe PAH. Further mechanistic studies are warranted.

Keyphrases

angiotensin converting enzyme
pulmonary arterial hypertension
angiotensin ii
pulmonary artery
pulmonary hypertension
endothelial cells
polycyclic aromatic hydrocarbons
induced pluripotent stem cells
pluripotent stem cells
case control