Angiotensin converting enzyme 2 and angiotensin (1-7) axis in pulmonary arterial hypertension.
Julio SandovalLeonardo Del Valle-MondragonFelipe MassoNayeli ZayasTomás PulidoRicardo TeijeiroHector Gonzalez-PachecoRossana Olmedo-OcampoCarlos SisniegaAraceli Paez-ArenasGustavo Pastelin-HernandezJose Gomez-ArroyoNorbert F VoelkelPublished in: The European respiratory journal (2020)
The AngII-ACE2-Ang(1-7) axis appears to be altered in human PAH and we propose that this imbalance, in favour of AngII, plays a role in the pathogenesis of the severe PAH. Further mechanistic studies are warranted.