Pulmonary Infections in the Elderly Lead to Impaired Neutrophil Targeting, Which Is Improved by Simvastatin.

Elizabeth SapeyJaimin M PatelHannah L GreenwoodGeorgia M WaltonJon HazeldineCharendeep SadhraDhruv ParekhRachel C A DancerPeter NightingaleJanet M LordDavid R Thickett

Published in: American journal of respiratory and critical care medicine (2017)

Infections in older adults are associated with prolonged, impaired neutrophil migration, potentially contributing to poor outcomes. Statins improve neutrophil migration in vivo in health and in vitro in milder infective events, but not in severe sepsis, supporting their potential utility as an early intervention during pulmonary infections. Clinical trial registered with www.clinicaltrialsregister.eu (2011-002082-38).

Keyphrases

clinical trial
pulmonary hypertension
healthcare
randomized controlled trial
public health
cardiovascular disease
physical activity
mental health
acute kidney injury
early onset
human health
metabolic syndrome
phase ii
health information
climate change
insulin resistance
community dwelling
glycemic control