Insight into the significance of Foxp3 + tumor-infiltrating lymphocytes in squamous cell lung cancer.

Kazu ShiomiMasaaki IchinoeAi UshiwataKoji EshimaRyo NagashioShoko HayashiDai SonodaYasuto KondoRaito MaruyamaMasashi MikuboYoshiki MurakumoYukitoshi Satoh

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2024)

Our results showed that a large number of Foxp3 + TILs in the stroma may not associate with a poor prognosis in SQ-LC. To use the seemingly complicated information of Foxp3 + TILs as biomarkers, better understanding the diversity and heterogeneity of Foxp3 + TILs and analyzing their subpopulations that increase in the TME may be needed.

Keyphrases

regulatory t cells
poor prognosis
squamous cell
long non coding rna
dendritic cells
single cell
peripheral blood
mass spectrometry
immune response