Intracellular Enzyme-Responsive Profluorophore and Prodrug Nanoparticles for Tumor-Specific Imaging and Precise Chemotherapy.
Qing PeiShaojin LuJunli ZhouBowen JiangChaonan LiZhigang XieXiabin JingPublished in: ACS applied materials & interfaces (2021)
Responsive drug delivery systems possess great potential in disease diagnosis and treatment. Herein, we develop an activatable prodrug and fluorescence imaging material by engineering the endogenous NAD(P)H:quinone oxidoreductase-1 (NQO1) responsive linker. The as-prepared nanomaterials possess the NQO1-switched drug release and fluorescence enablement, which realizes the tumor-specific chemotherapy and imaging in living mice. The enzyme-sensitive prodrug nanoparticles exhibit selectively potent anticancer performance to NQO1-positive cancer and ignorable off-target toxicity. This work provides an alternative strategy for constructing smart prodrug nanoplatforms with precision, selectivity, and practicability for advanced cancer imaging and therapy.
Keyphrases
- drug release
- cancer therapy
- fluorescence imaging
- drug delivery
- high resolution
- advanced cancer
- photodynamic therapy
- palliative care
- locally advanced
- type diabetes
- metabolic syndrome
- young adults
- bone marrow
- papillary thyroid
- quantum dots
- reactive oxygen species
- rectal cancer
- radiation therapy
- risk assessment
- adipose tissue
- human health
- childhood cancer