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Leptin signaling in vagal afferent neurons supports the absorption and storage of nutrients from high-fat diet.

Kuei-Pin HuangMichael L GoodsonWendie VangHui LiAmanda J PageHelen E Raybould
Published in: International journal of obesity (2005) (2020)
Impairment of leptin signaling in VAN reduces responsiveness to gastrointestinal signals, which reduces intestinal absorption of carbohydrates and de novo lipogenesis resulting in reduced long-term energy storage. This study reveals a novel role of vagal afferents to support digestion and energy storage that may contribute to the effectiveness of vagal blockade to induce weight loss.
Keyphrases
  • high fat diet
  • weight loss
  • insulin resistance
  • adipose tissue
  • randomized controlled trial
  • systematic review
  • spinal cord
  • heavy metals
  • type diabetes
  • skeletal muscle
  • spinal cord injury
  • anaerobic digestion