Propofol promotes osteoclastic bone resorption by increasing DC-STAMP expression.
Eun-Jung KimHyung Joon KimSeong Wan BaikKyung Hoon KimSie Jeong RyuCheul-Hong KimSang-Wook ShinPublished in: Journal of dental anesthesia and pain medicine (2018)
We have demonstrated that propofol enhances osteoclast differentiation and maturation, and subsequently increases bone resorption. Additionally, we identified the regulatory pathway underlying osteoclast cell-cell fusion, which was enhanced by propofol through p38-mediated DC-STAMP expression.