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Long-lived humans have a unique plasma sphingolipidome.

Irene PradasMariona JovéKevin HuynhMarta InglesConsuelo BorrasNatalia Mota-MartorellJose Daniel Galo-LiconaJosep PuigJose ViñaPeter J MeikleReinald Pamplona
Published in: The journals of gerontology. Series A, Biological sciences and medical sciences (2021)
A species-specific lipidome profile is an inherent feature linked to longevity in the animal kingdom. However, there is a lack of lipidomic studies on human longevity. Here we use mass spectrometry based lipidomics to detect and quantify 151 sphingolipid molecular species and use these to define a phenotype of healthy humans with exceptional lifespan. Our results demonstrate that this profile specifically comprises a higher content of complex glycosphingolipids (hexosylceramides and gangliosides), and lower levels of ceramide species from the de novo pathway, sphingomyelin and sulfatide; while for ceramide-derived signaling compounds, their content remains unchanged. Our findings suggest that structural glycosphingolipids may be more relevant to achieve the centenarian condition than signaling sphingolipids.
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