Poly-lactic acid nanoparticles (PLA-NP) promote physiological modifications in lung epithelial cells and are internalized by clathrin-coated pits and lipid rafts.

Camila Macedo da LuzMatthew Samuel Powys BoylesPriscila Falagan-LotschMariana Rodrigues PereiraHenrique Rudolf TutumiEidy de Oliveira SantosNathalia Balthazar MartinsMartin HimlyAniela SommerIlse FoissnerAlbert DuschlJosé Mauro GranjeiroPaulo Emílio Corrêa Leite

Published in: Journal of nanobiotechnology (2017)

These data demonstrate that PLA-NP are internalized and, in general, tolerated by A549 cells, with no cytotoxicity and no secretion of pro-inflammatory mediators. However, PLA-NP exposure may induce modification of biological functions of A549 cells, which should be considered when designing drug delivery systems. Moreover, the pathways of PLA-NP internalization we detected could contribute to the improvement of selective uptake strategies.

Keyphrases

induced apoptosis
cell cycle arrest
lactic acid
endoplasmic reticulum stress
cell death
electronic health record
machine learning
artificial intelligence