The Effects of Acute and Chronic Alcohol Administration and Withdrawal on Bone Microstructure, Mechanical Strength, and Remodeling Protein Expression and Their Relation to an Antioxidant and FGF23 In Vivo.
Syed Alhafiz Syed HashimIsa Naina MohamedNorazlina MohamedPublished in: Biomedicines (2024)
Alcohol's detrimental effects on bone health are well established, yet some literature suggests moderate consumption may offer benefits. With alcohol use on the rise, we investigate the impact of acute and chronic alcohol administration, along with withdrawal, on male Wistar rat femurs. We observed a transient cortical thickness increase with acute alcohol (AA) compared to chronic exposure (CA) but no significant changes in trabecular parameters or mechanical properties. High osteocalcin and osteopontin expression levels were noted in AA, alongside elevated RANKL expression. Conversely, CA showed low TRAP levels. FGF23 expression significantly increased during alcohol withdrawal (AW), while GPX decreased after chronic exposure but rose during withdrawal. Although mechanical strength changes were insignificant, biochemical shifts suggest alcohol exposure promotes bone resorption, reduces antioxidant protection, and potentially hampers active vitamin D and phosphate reabsorption via FGF23 upregulation.
Keyphrases
- poor prognosis
- drug induced
- liver failure
- bone mineral density
- alcohol consumption
- oxidative stress
- bone loss
- respiratory failure
- healthcare
- systematic review
- public health
- soft tissue
- aortic dissection
- long non coding rna
- signaling pathway
- mental health
- postmenopausal women
- binding protein
- high intensity
- intensive care unit
- optical coherence tomography
- immune response
- health information
- bone regeneration
- subarachnoid hemorrhage
- blood brain barrier