A mouse model of short-term, diet-induced fatty liver with abnormal cardiolipin remodeling via downregulated Tafazzin gene expression.

Toshihiro SakuraiZhen ChenArisa YamahataTakahiro HayasakaHiroshi SatohHirotaka SekiguchiHitoshi ChibaShu-Ping Hui

Published in: Journal of the science of food and agriculture (2021)

A HCD modulated the fatty acid composition of CL and MLCL via Tafazzin in the liver, which could lead to mitochondrial dysfunction. This model may be useful for elucidating the relationship between fatty liver and mitochondrial dysfunction. © 2021 Society of Chemical Industry.

Keyphrases

fatty acid
gene expression
mouse model
dna methylation