Altered DNA methylation pattern reveals epigenetic regulation of Hox genes in thoracic aortic dissection and serves as a biomarker in disease diagnosis.

Peiru LiuJing ZhangDuo DuDandan ZhangZelin JinWenqing QiuXiushi ZhouShulong DongMengyu ZhouHeyu ZhaoWei ZhangJiakang MaShaoyang SunWeiguo FuYun LiuLixin Wang

Published in: Clinical epigenetics (2021)

These findings showed an altered epigenetic regulation in TAD patients. This altered epigenetic regulation and subsequent altered expression of genes associated with vasculature and heart development, such as Hox family genes, may contribute to the loss of aortic integrity and TAD pathogenesis. Additionally, the cfDNA methylation in TAD was highly disease specific, which can be used as a non-invasive biomarker for disease prediction.

Keyphrases

dna methylation
genome wide
aortic dissection
end stage renal disease
heart failure
poor prognosis
newly diagnosed
ejection fraction
gene expression
spinal cord
prognostic factors
peritoneal dialysis
coronary artery
binding protein