Preeclampsia and Gestational Hypertension: Biochemical and Antioxidant Features in Vitro Might Help Understand Different Outcomes.
Victoria Elizabeth GalvãoRicardo de Carvalho CavalliValéria Cristina SandrimPublished in: Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia (2021)
Our findings suggest that KI alleviates oxidative stress leading to decreased HO-1 expression; plasma from preeclamptic women did not induce the enzyme's expression in HUVECs, and we hypothesize that this is possibly due to inhibitory post-transcriptional mechanisms in response to overexpression of this enzyme during early pregnancy.
Keyphrases
- oxidative stress
- poor prognosis
- pregnancy outcomes
- blood pressure
- transcription factor
- pregnant women
- weight gain
- gene expression
- polycystic ovary syndrome
- binding protein
- early onset
- squamous cell carcinoma
- ischemia reperfusion injury
- adipose tissue
- signaling pathway
- type diabetes
- anti inflammatory
- mouse model
- physical activity
- neoadjuvant chemotherapy
- pi k akt
- skeletal muscle
- breast cancer risk
- heat stress