Regulation of Oxidative Stress and Apoptosis in Streptozotocin-Induced Diabetic Rats by Egyptian Sidr Honey.
Bishoy El-AaragSahar Bahgat ShehataIslam M El-GarawaniHesham R El-SeediAmany Ebrahim NofalPublished in: Chemistry & biodiversity (2024)
Diabetes mellitus is a global health issue characterized by hyperglycemia which leads over time to severe damage to numerous tissues. The present study aimed to estimate the effect of Egyptian Sidr honey against streptozotocin (STZ)-induced diabetes in rats. Diabetic rats were treated with Sidr honey daily for 4 consecutive weeks. The biochemical profile of blood samples was measured. Furthermore, the activity of antioxidant enzymes, nitric oxide (NO), and malonaldehyde (MDA) were examined in hepatic and pancreatic tissues. Moreover, the expression of Bax, Caspase-3, and Bcl2 proteins were measured. Results revealed that the capability of Sidr honey to decline the elevated blood glucose and fructosamine levels. Also, the honey decreased the levels of NO and MDA. Furthermore, it regulated the antioxidant enzymes activity. Moreover, it reduced the expression levels of Caspase-3 and Bax while increased the Bcl2 level. In conclusion, Sidr honey can regulate hyperglycemia, oxidative stress, apoptosis, and antioxidant enzymes in STZ-induced diabetic rats.
Keyphrases
- diabetic rats
- oxidative stress
- induced apoptosis
- ischemia reperfusion injury
- dna damage
- blood glucose
- nitric oxide
- global health
- cell death
- glycemic control
- gene expression
- cardiovascular disease
- cell cycle arrest
- breast cancer cells
- blood pressure
- cell proliferation
- skeletal muscle
- transcription factor
- binding protein
- heat shock
- adipose tissue
- endothelial cells
- high fat diet