The chimera-type galectin-3 is a positive modulator of trophoblast functions with dysregulated expression in gestational diabetes mellitus.
Nancy FreitagIrene Tirado-GonzálezGabriela BarrientosMarie CohenSilvia DaherDebra Goldman-WohlLucia Mincheva-NilssonConstance M JohnUdo JeschkeSandra M BloisPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2020)
Our results reveal a physiological role for gal-3 during pregnancy, promoting proper trophoblast functions associated with healthy gestation. GDM is associated with a failure to increase circulating gal-3 levels late in gestation. Thus, dysregulation of gal-3 may indicate a contribution of the chimera-type lectin to this adverse pregnancy outcome.