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Two-stage optimal designs with survival endpoint when the follow-up time is restricted.

Guogen ShanHua Zhang
Published in: BMC medical research methodology (2019)
The proposed two-stage minimax and optimal designs with survival endpoint are recommended for use in practice to shorten the study length of clinical trials.
Keyphrases
  • clinical trial
  • primary care
  • healthcare
  • free survival
  • randomized controlled trial
  • quality improvement
  • finite element analysis
  • study protocol