Covid-19 in cystic fibrosis patients compared to the general population: Severity and virus-host cell interactions.
Fabiana CicirielloFrancesco PanarielloPaola MedinoArianna BiffiFederico AlghisiChiara RosazzaPatrizia AnnunziataValentina BouchèAntonio GrimaldiDaniela GuidoneArianna VenturiniGianfranco AlicandroMassimo OggioniPellegrino CerinoGiulia PaiolaAndrea GramegnaAlessandro FiocchiAlessandra BanderaVincenzina LucidiDavide CacchiarelliLuis J V GaliettaCarla ColomboPublished in: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society (2024)
COVID-19 does not seem to be more severe in CF, possibly due to factors intrinsic to this population: the lower expression of ribosomal genes may downregulate the protein translation machinery, thus creating an unfavorable environment for viral replication.
Keyphrases
- cystic fibrosis
- sars cov
- coronavirus disease
- end stage renal disease
- ejection fraction
- newly diagnosed
- pseudomonas aeruginosa
- chronic kidney disease
- poor prognosis
- prognostic factors
- single cell
- binding protein
- genome wide
- cell therapy
- peritoneal dialysis
- dna methylation
- chronic obstructive pulmonary disease
- mesenchymal stem cells
- transcription factor
- drug induced
- patient reported