Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation.
Dandan JiaHuijie ZhangTiemin LiuRu WangPublished in: Metabolites (2024)
Adipose tissue undergoes changes with aging, leading to increased adiposity, inflammatory cell infiltration, reduced angiogenesis, heightened oxidative stress, and alterations in its metabolic function. Regular exercise has been recognized as a powerful intervention that can positively influence adipose tissue health and mitigate the effects of aging. However, the molecular mechanisms underlying the benefits of regular exercise on aging adipose tissue function remain poorly understood. Adipokines released through regular exercise play a potential role in mitigating adipose tissue aging, enhancing the metabolism of glucose and lipids, reducing inflammation and fibrosis, and promoting fat browning and thermogenesis. This review comprehensively summarizes the benefits of regular exercise in addressing the age-related decline in adipose tissue function. Utilizing relevant examples of this approach, we address the possibility of designing therapeutic interventions based on these molecular mechanisms.
Keyphrases
- adipose tissue
- insulin resistance
- high intensity
- oxidative stress
- high fat diet
- physical activity
- resistance training
- healthcare
- public health
- randomized controlled trial
- stem cells
- type diabetes
- endothelial cells
- mental health
- bone marrow
- diabetic rats
- high fat diet induced
- social media
- single molecule
- health information
- skeletal muscle
- induced apoptosis
- endoplasmic reticulum stress
- cell therapy
- mesenchymal stem cells
- wound healing