Integrin-targeted quantitative optoacoustic imaging with MRI correlation for monitoring a BRAF/MEK inhibitor combination therapy in a murine model of human melanoma.

Philipp M KazmierczakNeal C BurtonGeorg KeinrathHeidrun Hirner-EppenederMoritz J SchneiderRalf S EschbachMaurice HeimerOlga SolyanikAndrei TodicaMaximilian F ReiserJens RickeClemens C Cyran

Published in: PloS one (2018)

αvβ3-integrin-targeted optoacoustic imaging allowed for the early non-invasive monitoring of a BRAF/MEK inhibitor combination therapy in a murine model of human melanoma, adding molecular information on tumor receptor status to morphology-based tumor response criteria.

Keyphrases

combination therapy
high resolution
endothelial cells
induced pluripotent stem cells
cancer therapy
pluripotent stem cells
magnetic resonance imaging
pi k akt
healthcare
metastatic colorectal cancer
cell proliferation
mass spectrometry
skin cancer
cell migration
fluorescence imaging
photodynamic therapy