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Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins.

Lourdes Valdés-SánchezSofia M CaladoBerta de la CerdaAna AramburuAna Belén García-DelgadoSimone MassaliniAdoración Montero-SánchezVaibhav BhatiaEduardo Rodríguez-BocanegraAndrea Diez-LloretDaniel Rodríguez-MartínezChristina ChakarovaShom S BhattacharyaFrancisco-Javier Díaz-Corrales
Published in: Molecular medicine (Cambridge, Mass.) (2019)
Our data suggests that a mechanism haploinsufficiency and dominant-negative is involved in retinal degeneration due to mutations in PRPF31. HSP70 over-expression might be a new therapeutic target for the treatment of retinal degeneration due to PRPF31 mutations.
Keyphrases
  • optical coherence tomography
  • heat shock protein
  • diabetic retinopathy
  • heat shock
  • heat stress
  • poor prognosis
  • optic nerve
  • electronic health record
  • big data
  • oxidative stress
  • combination therapy
  • deep learning