Diagnosis of multisystem inflammatory syndrome in children by a whole-blood transcriptional signature.
Heather R JacksonLuca MigliettaDominic Habgood-CooteGiselle D'SouzaPriyen ShahSamuel NicholsOrtensia VitoOliver PowellMaisey Salina DavidsonChisato ShimizuPhilipp Kwame Abayie AgyemanCoco R BeudekerKaren Brengel-PesceEnitan D CarrolMichael J CarterTisham DeIrini EleftheriouMarieke EmontsCristina EpalzaPantelis GeorgiouRonald De GrootKaty FidlerColin FinkDaniëlle van KeulenTaco KuijpersHenriette A MollIrene PapatheodorouStephane PaulusMarko PokornAndrew J PollardIrene Rivero-CallePablo RojoFatou SeckaLuregn J SchlapbachAdriana H TremouletMaria TsoliaEffua UsufMichiel Van Der FlierUlrich von BothClementien VermontShunmay YeungDace ZavadskaWerner ZenzLachlan J M CoinAubrey CunningtonJane C BurnsVictoria WrightFederico Martinon-TorresJethro Adam HerbergJesus Rodriguez ManzanoMyrsini KaforouMichael Levinnull nullPublished in: Journal of the Pediatric Infectious Diseases Society (2023)
MIS-C can be distinguished from KD, DB, and DV groups using a 5-gene blood RNA expression signature. The small number of genes in the signature, and good performance in both discovery and validation sets should enable the development of a diagnostic test for MIS-C.