TREX1 Inactivation Unleashes Cancer Cell STING-Interferon Signaling and Promotes Antitumor Immunity.

Tetsuo Tani Haritha Mathsyaraja Marco Campisi Ze-Hua Li Koji Haratani Caroline G Fahey Keiichi Ota Navin R Mahadevan Yingxiao Shi Shin Saito Kei Mizuno Tran C Thai Nobunari Sasaki Mizuki Homme Choudhury Fabliha B Yusuf Adam Kashishian Jipsa Panchal Min Wang Benjamin J Wolf Thanh U Barbie Cloud P Paweletz Prafulla C Gokhale David R Liu Ravindra Uppaluri Shunsuke Kitajima Jennifer Cain David A Barbie

Published in: Cancer discovery (2024)

STING-IFN signaling in cancer cells promotes tumor cell immunogenicity. Inactivation of the DNA exonuclease TREX1, which is adaptively upregulated to limit pathway activation in cancer cells, recruits immune effector cells and primes NK cell-mediated killing. Targeting TREX1 has substantial therapeutic potential to amplify cancer cell immunogenicity and overcome ICB resistance. This article is featured in Selected Articles from This Issue, p. 695.

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