Decarboxylative N -Formylation of Amines with Glyoxylic Acid Promoted by H 2 O 2 .

A novel method for the synthesis of formamides through the decarboxylative N -formylation of amines with glyoxylic acid has been developed. This transformation provides an efficient protocol for the synthesis of various formamides with moderate to excellent yields, and it can accommodate a wide range of functional groups under metal free and base free conditions. In addition, the large-scale experiments and high chemoselectivity have shown great potential application of this strategy.