Effects of carvedilol and metoprolol on the myocardium during mechanical unloading in a rat heterotopic heart transplantation model.

Geena KimHong Ryang KilCheng QuanSang Su Lee

Published in: Cardiology in the young (2021)

Compared to carvedilol treatment, metoprolol treatment improved myocardial fibrosis and SERCA2a expression to a greater extent; however, neither drug prevented myocardial apoptosis.

Keyphrases

oxidative stress
left ventricular
poor prognosis
cell death
signaling pathway
combination therapy
cell proliferation
replacement therapy
smoking cessation
liver fibrosis