Mechanical ventilation enhances Acinetobacter baumannii-induced lung injury through JNK pathways.
Tzyy-Bin TsayWan-Hsuan ChangChing-Mei HsuLee-Wei ChenPublished in: Respiratory research (2021)
A.b. is potent in inducing neutrophil infiltration in the lungs and total protein in the BALF. MV enhances A.b.-induced lung injury through an increase in the expression of VCAM and IL-6 levels in the BALF and a decrease in the bacteria-killing activity of AMs. A lower inflammation level in JNK1-/- mice indicates that A.b.-induced VAP causes lung injury through JNK signaling pathway in the lungs.
Keyphrases
- signaling pathway
- mechanical ventilation
- high glucose
- acinetobacter baumannii
- diabetic rats
- cell death
- induced apoptosis
- oxidative stress
- multidrug resistant
- poor prognosis
- pseudomonas aeruginosa
- acute respiratory distress syndrome
- pi k akt
- type diabetes
- skeletal muscle
- cystic fibrosis
- extracorporeal membrane oxygenation
- small molecule
- long non coding rna
- respiratory failure
- stress induced
- endoplasmic reticulum stress
- amino acid