Serotonin Exhibits Accelerated Bleomycin-Induced Pulmonary Fibrosis through TPH1 Knockout Mouse Experiments.
Jingyao ZhangRuixia CuiYang FengWeiman GaoJianbin BiZeyu LiChang LiuPublished in: Mediators of inflammation (2018)
5-HT aggravated pulmonary fibrosis mainly by promoting the inflammation, exudation of proteins and cells, oxidative stress, and upregulation of fibrosis-associated genes in the lung tissues.
Keyphrases
- pulmonary fibrosis
- oxidative stress
- induced apoptosis
- diabetic rats
- signaling pathway
- cell cycle arrest
- endoplasmic reticulum stress
- high glucose
- dna damage
- ischemia reperfusion injury
- genome wide
- poor prognosis
- gene expression
- cell proliferation
- drug induced
- cell death
- transcription factor
- bioinformatics analysis
- heat shock
- wild type