Clinical and structural brain correlates of hypomimia in early-stage Parkinson's disease.
Frederic SampedroSaul-Indra Martinez-HortaAndrea Horta-BarbaMichel J GrotheMiguel A Labrador-EspinosaSilvia JesúsAstrid Adarmes-GomezFatima CarrilloArnau Puig-DaviFlorinda Roldan-LoraMiquel Aguilar-BarberaPau PastorSonia Escalante ArroyoBerta Solano VilaAnna Cots-ForasterJavier Ruiz-MartínezFrancisco Carrillo-PadillaMercedes Pueyo-MorlansIsabel Gonzalez-AramburuJon Infante-CeberioJorge Hernandez-VaraOriol de Fabregues-BoixarTeresa de Deus FonticobaAsunción AvilaMartínez-Castrillo Juan CarlosHelena Bejr-KasemAntonia CampolongoBerta Pascual-SedanoPablo Martínez-MartínDiego Santos GarcíaPablo Mirnull nullPedro José García-RuizJaime KulisevskyPublished in: European journal of neurology (2022)
Reduced facial expressivity in PD is related to the severity of symptoms of apathy and is mediated by the dysfunction of brain systems involved in motor control and in the recognition, integration and expression of emotions. Therefore, hypomimia in PD may be conceptualized not exclusively as a motor symptom but as a consequence of a multidimensional deficit leading to a symptom where motor and non-motor aspects converge.