Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging.
Christian SchmidkonzSimon RauberArmin AtzingerRahul AgarwalTheresa Ida GötzAlina SoareMichael CordesOlaf PranteChristina BergmannArnd KleyerPhilipp RittSimone MaschauerPeter HennigJohannes TomsMarkus KöhnerBernhard MangerJohn H StoneUwe HaberkornTobias BaeuerleJörg H W DistlerAbbas AgaimyTorsten KuwertLarissa Valor-MéndezAndreas RammingPublished in: Annals of the rheumatic diseases (2020)
FAP-specific PET/CT permits the discrimination between inflammatory and fibrotic activity in IgG4-related disease. This finding may profoundly change the management of certain forms of immune-mediated disease, such as IgG4-related disease, as subtypes dominated by fibrosis may require different approaches to control disease progression, for example, specific antifibrotic agents rather than broad spectrum anti-inflammatory treatments such as glucocorticoids.
Keyphrases
- pet ct
- disease activity
- rheumatoid arthritis
- systemic lupus erythematosus
- anti inflammatory
- oxidative stress
- systemic sclerosis
- high resolution
- ankylosing spondylitis
- rheumatoid arthritis patients
- computed tomography
- juvenile idiopathic arthritis
- positron emission tomography
- mass spectrometry
- small molecule
- binding protein
- protein protein
- amino acid
- pulmonary fibrosis