Cord Blood Plasma and Placental Mesenchymal Stem Cells-Derived Exosomes Increase Ex Vivo Expansion of Human Cord Blood Hematopoietic Stem Cells While Maintaining Their Stemness.
Rasha S TelebAmal Abdul-HafezAmira OthmanAhmed El-Abd AhmedAbdelrahman A ElsaidHattan ArifAhmed A ZareaMohammed AbdulmageedHend MohamedSherif Abdelfattah IbrahimRanga P ThiruvenkataramaniTarek MohamedMasamitsu KanadaBurra V MadhukarMyrna Gonzalez ArellanoMohammed M SayedHeba M QubaisySaid A OmarPublished in: Cells (2023)
CBP- and placental-derived exosomes are associated with significant ex vivo expansion of UCB HSCs, while maintaining their primitive characters and may eliminate the need for transplantation of an additional unit of UCB.